Supercritical fluid chromatography (SFC) has traditionally been viewed as a powerful tool for chiral separations. Recent research shows a surge in SFC being used for achiral applications, particularly in the pharmaceutical sector. This talk will explore the theory behind SFC, emphasizing its advantages over HPLC, including:

• SFC is a Green technology: Reduced organic solvent consumption
• Faster separations: Lower viscosity CO₂ can be used at higher flow rates
• Broad applicability: Effective for both chiral and achiral molecules, and offers orthogonal selectivity and separation

We will delve into key components for SFC method development, such as modifier selection, column temperature, back pressure, and flow rate optimization. Additionally, we will showcase novel applications of SFC beyond chiral separations, including analysis of lipids, small metabolites, food nutrients, and environmental contaminants.

We will compare SFC and HPLC systems, and demonstrate SFC's compatibility with various detectors and common packed columns. Finally, the presentation will emphasize the ease of use of SFC, making it a readily accessible technique for chromatographers familiar with HPLC.

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Nivesh K. Mittal, MBA, MBA, PhD

Nivesh is the LC Product Manager at Shimadzu Scientific Instruments (SSI), the North American Subsidiary for Shimadzu Corporation Japan. He has an extensive background in drug product development and cGMP manufacturing of parenteral hard to manufacture drug products such as nanoparticles and insoluble APIs. Before joining SSI, Nivesh was a Product Development Scientist at KaloCyte, where he was developing a blood substitute utilizing purified hemoglobin packed into nanoparticulate vesicles. Before that he was a Research Scientist and Interim Director at the Plough Center for Sterile Drug Delivery Solutions at the University of Tennessee Health Science Center, Memphis. Nivesh holds a BS and MS in Biotechnology, a PhD in Pharmaceutical Sciences, and an MBA. He comes from a business family in India where from his love and passion for business and management originate.

Nivesh’s current research interests include the development of analytical methods, hard to manufacture pharma and biotech products and lyophilization cycle and formulation development. His PhD work focuses the development of a nanomedicine for a water insoluble molecule for the treatment of blood cancers. He has numerous publications in the field and holds a patent application for the system he developed in his PhD. Nivesh has been invited to deliver presentations and his talks are highly acclaimed by peers in the field.

Evgenia Barannikova, PhD

Evgenia Barannikova, Ph.D., is an Assistant LC Product Manager at Shimadzu Scientific Instruments. Evgenia received her doctoral degree in Chemistry from the University of Maryland Baltimore County with focus on bio-templated materials and peptide affinity for different targets. She has taught undergraduate level analytical and instrumental chemistry labs, training students to utilize a range of analytical instruments including HPLC with a focus on pharmaceutical and environmental applications. Evgenia joined the LC group at Shimadzu Scientific Instruments in January 2020, since then she has provided multiple instrument demonstrations, trainings, and technical support sessions to SSI’s field tech support scientists, sales engineers, and current and prospective customers. In between these activities, Evgenia enjoys working on lab projects leading to application notes and developing customer-facing materials using cutting edge technology and HPLC instrumentation at SSI.